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CSNK2B Antibody
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P67870 |
| Other Accession | P67874, P67873, P67872, P67871, P67869, P67868, NP_001311.3 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Chicken, Pig, Rabbit, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Clone/Animal Names | 260CT10.1.1 |
| Calculated MW | 24942 Da |
| Gene ID | 1460 |
|---|---|
| Other Names | Casein kinase II subunit beta, CK II beta, Phosvitin, Protein G5a, CSNK2B, CK2N, G5A |
| Target/Specificity | This CSNK2B monoclonal antibody is generated from mouse immunized with CSNK2B recombinant protein. |
| Dilution | WB~~1:1000 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CSNK2B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CSNK2B (HGNC:2460) |
|---|---|
| Synonyms | CK2N, G5A |
| Function | Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610). Participates in Wnt signaling (By similarity). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.
References
Shehata, M., et al. Blood 116(14):2513-2521(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Olsen, B.B., et al. Int. J. Oncol. 36(5):1175-1182(2010)
Shi, Y., et al. BMB Rep 42(12):840-845(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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