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MAP3K11 Antibody (ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q16584 |
| Other Accession | NP_002410.1 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM,k |
| Clone/Animal Names | 230CT5.3.1 |
| Calculated MW | 92688 Da |
| Gene ID | 4296 |
|---|---|
| Other Names | Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase, MAP3K11 (HGNC:6850) |
| Target/Specificity | This MAP3K11 monoclonal antibody is generated from mouse immunized with MAP3K11 recombinant protein. |
| Dilution | WB~~1:500~1000 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAP3K11 Antibody (ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAP3K11 (HGNC:6850) |
|---|---|
| Function | Activates the JUN N-terminal pathway. Required for serum- stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen- stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Location is cell cycle dependent |
| Tissue Location | Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
References
Chen, J., et al. Oncogene 29(31):4399-4411(2010)
Liou, G.Y., et al. Biochem. J. 427(3):435-443(2010)
Mishra, P., et al. Mol. Endocrinol. 24(3):598-607(2010)
Rangasamy, V., et al. Cancer Res. 70(4):1731-1740(2010)
Velho, S., et al. Hum. Mol. Genet. 19(4):697-706(2010)
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