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PAX6 Antibody
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P26367 |
| Other Accession | P63015, Q1LZF1, NP_001121084.1, NP_001595.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM,K |
| Clone/Animal Names | 193CT15.2.2 |
| Calculated MW | 46683 Da |
| Gene ID | 5080 |
|---|---|
| Other Names | Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6, AN2 |
| Target/Specificity | This PAX6 monoclonal antibody is generated from mouse immunized with PAX6 recombinant protein. |
| Dilution | WB~~1:100~1000 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PAX6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PAX6 |
|---|---|
| Synonyms | AN2 |
| Function | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1- mediated gene expression (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P63015}. [Isoform 5a]: Nucleus {ECO:0000250|UniProtKB:P63016} |
| Tissue Location | [Isoform 1]: Expressed in lymphoblasts. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding either the same or different isoform have been found for this gene. [provided by RefSeq].
References
Gosmain, Y., et al. J. Biol. Chem. 285(43):33381-33393(2010)
Vuzman, D., et al. Biophys. J. 99(4):1202-1211(2010)
Zhang, X., et al. Cell Stem Cell 7(1):90-100(2010)
Bremond-Gignac, D., et al. Mol. Vis. 16, 1705-1711 (2010) :
Cai, F., et al. Mol. Vis. 16, 1141-1145 (2010) :
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