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Anti-DFNA5 Antibody
Rabbit Anti Human Polyclonal Antibody
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- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | O60443 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 54555 Da |
| Dilution | ELISA, IHC-P (10 µg/ml) |
| Gene ID | 1687 |
|---|---|
| Alias Symbol | DFNA5 |
| Other Names | DFNA5, ICERE-1, Deafness, autosomal dominant 5, ICERE1 |
| Target/Specificity | Human DFNA5 |
| Reconstitution & Storage | Caprylic acid and ammonium sulfate precipitation |
| Precautions | Anti-DFNA5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GSDME {ECO:0000303|PubMed:28459430, ECO:0000312|HGNC:HGNC:2810} |
|---|---|
| Function | [Gasdermin-E]: Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis (PubMed:27281216, PubMed:28459430, PubMed:33852854, PubMed:35594856, PubMed:36607699). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:28459430). |
| Cellular Location | [Gasdermin-E, N-terminal]: Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6} |
| Tissue Location | Expressed in cochlea (PubMed:9771715). Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta (PubMed:9771715). |
Research Areas
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