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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-HEC1 / NDC80 Antibody (C-Terminus)
Anti-HEC1 / NDC80 Antibody (C-Terminus)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC |
|---|---|
| Primary Accession | O14777 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 73913 Da |
| Dilution | Flo (1 - 3 µg/10E6 cells), IHC-P (10 µg/ml), WB (0.5 - 1 µg/ml) |
| Gene ID | 10403 |
|---|---|
| Alias Symbol | NDC80 |
| Other Names | NDC80, HEC1, Kinetochore protein Hec1, Kinetochore associated 2, HEC, HsHec1, HsNDC80, KNTC2, TID3 |
| Target/Specificity | Endogenous levels of human HEC1. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-HEC1 / NDC80 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NDC80 |
|---|---|
| Synonyms | HEC, HEC1, KNTC2 |
| Function | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205). |
| Cellular Location | Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase (PubMed:14699129) Localizes specifically to the outer plate of the kinetochore (PubMed:14699129). |
Research Areas
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$ 467.50
Cat# ALS18464
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