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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-FEN1 Antibody (C-Terminus)
Anti-FEN1 Antibody (C-Terminus)
Rabbit Anti Human Polyclonal Antibody
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- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P39748 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42593 Da |
| Dilution | IHC-P (10 µg/ml), WB (0.5 - 1 µg/ml) |
| Gene ID | 2237 |
|---|---|
| Alias Symbol | FEN1 |
| Other Names | FEN1, DNase IV, FEN-1, HFEN-1, Flap endonuclease 1, MF1, RAD2, Maturation factor 1, Maturation factor-1 |
| Target/Specificity | Endogenous levels of human FEN-1 protein. Positive Control: HeLa, HepG2 and HEK293. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-FEN1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FEN1 {ECO:0000255|HAMAP-Rule:MF_03140} |
|---|---|
| Synonyms | RAD2 |
| Function | Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. |
| Cellular Location | [Isoform 1]: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 467.50
Cat# ALS18459
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