Anti-Geminin Antibody (N-Terminus)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | O75496 |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 23565 Da |
Dilution | ELISA (0.05 - 0.2 µg/ml), IHC-P (10 µg/ml), WB (0.5 - 1 µg/ml) |
Gene ID | 51053 |
---|---|
Alias Symbol | GMNN |
Other Names | GMNN, Geminin |
Target/Specificity | Human geminin protein. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-Geminin Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GMNN |
---|---|
Function | Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:14993212, PubMed:20129055, PubMed:24064211, PubMed:9635433). It is degraded during the mitotic phase of the cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Its destruction at the metaphase- anaphase transition permits replication in the succeeding cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). |
Cellular Location | Cytoplasm. Nucleus. Note=Mainly cytoplasmic but can be relocalized to the nucleus. |
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