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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-RAB5A / RAB5 Antibody
Anti-RAB5A / RAB5 Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | P20339 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 23659 Da |
| Dilution | IF (1:50 - 1:200), IHC-P (1:100), WB (1:500 - 1:2000) |
| Gene ID | 5868 |
|---|---|
| Alias Symbol | RAB5A |
| Other Names | RAB5A, Ras-related protein Rab-5A, RAS-associated protein RAB5A, RAB5 |
| Target/Specificity | Human RAB5A / RAB5 |
| Reconstitution & Storage | Affinity purified |
| Precautions | Anti-RAB5A / RAB5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RAB5A |
|---|---|
| Synonyms | RAB5 |
| Function | Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:15378032, PubMed:16410077). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid- anchor. Melanosome. Cytoplasmic vesicle. Cell projection, ruffle {ECO:0000250|UniProtKB:P18066}. Membrane Cytoplasm, cytosol. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9CQD1}. Endosome membrane Note=Enriched in stage I melanosomes (PubMed:17081065). Alternates between membrane-bound and cytosolic forms (Probable) {ECO:0000269|PubMed:17081065, ECO:0000305} |
Research Areas
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$ 467.50
Cat# ALS18322
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