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Anti-IGFBP3 Antibody (aa130-179)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P17936 |
| Predicted | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 31674 Da |
| Dilution | ELISA, IHC-P (1:50), WB |
| Gene ID | 3486 |
|---|---|
| Alias Symbol | IGFBP3 |
| Other Names | IGFBP3, Binding protein 29, Binding protein 53, BP-53, IGF-binding protein 3, IGFBP-3, IBP-3, IBP3 |
| Target/Specificity | IGFBP-3 antibody detects endogenous levels of IGFBP-3. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-IGFBP3 Antibody (aa130-179) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IGFBP3 |
|---|---|
| Synonyms | IBP3 |
| Function | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF- independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP- 1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028). |
| Cellular Location | Secreted. Nucleus |
| Tissue Location | Expressed by most tissues. Present in plasma. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 555.50
Cat# ALS18048
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