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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-CANX / Calnexin Antibody (aa543-592)
Anti-CANX / Calnexin Antibody (aa543-592)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | P27824 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 67568 Da |
| Dilution | ELISA, IF, IHC-P (1:50), WB |
| Gene ID | 821 |
|---|---|
| Alias Symbol | CANX |
| Other Names | CANX, CNX, Calnexin, IP90, p90 |
| Target/Specificity | Calnexin (Ab-583) Antibody detects endogenous levels of total Calnexin protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-CANX / Calnexin Antibody (aa543-592) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CANX |
|---|---|
| Function | Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Mitochondrion membrane {ECO:0000250|UniProtKB:P24643}; Single-pass type I membrane protein. Melanosome membrane; Single-pass type I membrane protein. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232) Localizes to endoplasmic reticulum mitochondria-associated membrane (MAMs) that connect the endoplasmic reticulum and the mitochondria (By similarity). {ECO:0000250|UniProtKB:P24643, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:22314232} |
Research Areas
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Application Protocols
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$ 555.50
Cat# ALS18010
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