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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-HSD3B1 Antibody (clone 3C11-D4)
Anti-HSD3B1 Antibody (clone 3C11-D4)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P14060 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Clone Names | 3C11-D4 |
| Calculated MW | 42252 Da |
| Dilution | ELISA, IHC-P (3 - 10 µg/ml), WB |
| Gene ID | 3283 |
|---|---|
| Alias Symbol | HSD3B1 |
| Other Names | HSD3B1, 3BETAHSD, 3-beta-HSD I, 3BH, HSD3B, HSDB3A, HSDB3, Steroid Delta-isomerase, Trophoblast antigen FDO161G, Progesterone reductase, SDR11E1 |
| Target/Specificity | Human HSD3B1 |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-HSD3B1 Antibody (clone 3C11-D4) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HSD3B1 (HGNC:5217) |
|---|---|
| Synonyms | 3BH, HSDB3A |
| Function | A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo- Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone (PubMed:1401999, PubMed:2139411). Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein |
| Tissue Location | Placenta and skin (PubMed:1401999). Predominantly expressed in mammary gland tissue. |
Research Areas
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$ 533.50
Cat# ALS17852
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