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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-CD74 / CLIP Antibody (clone M-B741, Azide-free)
Anti-CD74 / CLIP Antibody (clone M-B741, Azide-free)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, FC |
|---|---|
| Primary Accession | P04233 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone Names | M-B741 |
| Calculated MW | 33516 Da |
| Dilution | Flo, IHC-P (20 µg/ml) |
| Gene ID | 972 |
|---|---|
| Alias Symbol | CD74 |
| Other Names | CD74, CD74 antigen, DHLAG, HLADG, HLA-DR-gamma, Ia-associated invariant chain, p33, MHC HLA-DR gamma chain, Ia-GAMMA |
| Target/Specificity | CD74 molecule of about 33 kd. |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-CD74 / CLIP Antibody (clone M-B741, Azide-free) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD74 (HGNC:1697) |
|---|---|
| Synonyms | DHLAG |
| Function | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Secreted. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane |
| Tissue Location | Detected in urine (at protein level). [Isoform p33]: In B cells, represents 70% of total CD74 expression. |
Research Areas
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$ 533.50
Cat# ALS17843
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