Anti-PPP2R4 Antibody (aa347-358)
Goat Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q15257 |
Predicted | Human, Mouse, Rat, Rabbit, Hamster, Monkey |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 40668 Da |
Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.5 - 2 µg/ml) |
Gene ID | 5524 |
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Alias Symbol | PPP2R4 |
Other Names | PPP2R4, PP2A phosphatase activator, PP2A subunit B isoform PR53, PTPA, PP2A, PP2A, subunit B, PR53 isoform, PR53 |
Target/Specificity | Human PPP2R4. This antibody is expected to recognize all reported isoforms (NP_821068.1; NP_066954.2; NP_821070.1). Reported variants NP_066954.2 and NP_821067.1 represent identical protein. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-PPP2R4 Antibody (aa347-358) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PTPA (HGNC:9308) |
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Synonyms | PPP2R4 |
Function | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) (PubMed:16916641, PubMed:36073231). Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase (PubMed:16916641). Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro) (PubMed:16916641). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex (PubMed:16916641). Is involved in apoptosis; the function appears to be independent from PP2A (PubMed:17333320). |
Cellular Location | Cytoplasm. Nucleus |
Tissue Location | Widely expressed. |
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