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Anti-TRPM8 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
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- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q7Z2W7 |
| Predicted | Human, Mouse, Rat, Rabbit, Hamster, Chicken, Horse, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 127685 Da |
| Dilution | IHC-P (2.4 µg/ml) |
| Gene ID | 79054 |
|---|---|
| Alias Symbol | TRPM8 |
| Other Names | TRPM8, CMR1, Cold-menthol receptor type 1, LTrpC-6, TRPP8, Trp-p8, LTRPC6 |
| Target/Specificity | Human TRPM8. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TRPM2 (60%). |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-TRPM8 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRPM8 |
|---|---|
| Synonyms | LTRPC6, TRPP8 |
| Function | Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin therefore plays a central role in the detection of environmental cold temperatures (PubMed:15306801, PubMed:15852009, PubMed:16174775, PubMed:25559186, PubMed:37857704). TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel (PubMed:15306801). In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (By similarity). May plays a role in prostate cancer cell migration (PubMed:16174775, PubMed:25559186). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Membrane raft {ECO:0000250|UniProtKB:Q8R4D5}. Endoplasmic reticulum membrane. Note=Lipid raft association modulates TRPM8 channel activity (By similarity) Located in the endoplasmic reticulum in prostate cancer cells (PubMed:11325849, PubMed:16174775). {ECO:0000250|UniProtKB:Q8R4D5, ECO:0000269|PubMed:11325849, ECO:0000269|PubMed:16174775} |
| Tissue Location | Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors. |
Research Areas
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$ 467.50
Cat# ALS17581
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