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Anti-NR5A1 / SF1 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q13285 |
| Predicted | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51636 Da |
| Dilution | IHC-P (2 - 18 µg/ml) |
| Gene ID | 2516 |
|---|---|
| Alias Symbol | NR5A1 |
| Other Names | NR5A1, AD4BP, Adrenal 4 binding protein, Adrenal 4-binding protein, ELP, Steroidogenic factor-1, SRXY3, Steroidogenic factor 1, Nuclear receptor AdBP4, Nuclear receptor elp, POF7, SF-1, SPGF8, Steroid hormone receptor Ad4BP, STF-1, FTZ1, FTZF1, Fushi ... |
| Target/Specificity | Human NR5A1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TRIM23 (47%). |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-NR5A1 / SF1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NR5A1 |
|---|---|
| Synonyms | AD4BP, FTZF1, SF1 |
| Function | Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:11479297, ECO:0000269|PubMed:27490115} |
| Tissue Location | High expressed in the adrenal cortex, the ovary, the testis, and the spleen (PubMed:9177385) |
Research Areas
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Application Protocols
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$ 467.50
Cat# ALS17484
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