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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-GNAO1 Antibody (aa50-100)
Anti-GNAO1 Antibody (aa50-100)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P09471 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40051 Da |
| Dilution | IHC-P (10 µg/ml), WB (0.5 - 1 µg/ml) |
| Gene ID | 2775 |
|---|---|
| Alias Symbol | GNAO1 |
| Other Names | GNAO1, GNAO, G-ALPHA-o, G0 Protein Alpha |
| Target/Specificity | Endogenous levels of mouse and rat G alpha(o). Predicted to react with human G alpha(o) according to sequence homology. Positive Control: Mouse and rat brain. |
| Reconstitution & Storage | Lyophilized from PBS, pH 7.4, 0.02% sodium azide. Store lyophilized at -20°C. The reconstituted product can be stored for short term at 4 °C or long term at -20 °C or below. Avoid freeze/thaw cycles. |
| Precautions | Anti-GNAO1 Antibody (aa50-100) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GNAO1 |
|---|---|
| Function | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:29925951). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase (By similarity). Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). |
| Cellular Location | Cell membrane. Membrane; Lipid-anchor |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 467.50
Cat# ALS17463
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