Anti-CACNA1E / Cav2.3 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q15878 |
Predicted | Human, Mouse, Rat, Rabbit |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 261731 Da |
Dilution | IHC-P (1:100), WB (1:500 - 1:1000) |
Gene ID | 777 |
---|---|
Alias Symbol | CACNA1E |
Other Names | CACNA1E, BII, Brain calcium channel II, Cav2.3, CACNL1A6, Alpha 1e, CACH6, Cchra1 |
Target/Specificity | Recognizes endogenous levels of Cav2.3 protein. |
Reconstitution & Storage | PBS, pH 7.3, 0.01% sodium azide, 30% glycerol. Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
Precautions | Anti-CACNA1E / Cav2.3 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CACNA1E |
---|---|
Synonyms | CACH6, CACNL1A6 |
Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. |
Cellular Location | Membrane; Multi-pass membrane protein. |
Tissue Location | Expressed in neuronal tissues and in kidney. |
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