Anti-APOA1 / Apolipoprotein A 1 Antibody
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | P02647 |
Predicted | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG2a |
Calculated MW | 30778 Da |
Dilution | IHC-P (5 µg/ml) |
Gene ID | 335 |
---|---|
Alias Symbol | APOA1 |
Other Names | APOA1, ApoA-I, APOAI, Apolipoprotein A-I, Apolipoprotein A1, Apo-AI |
Target/Specificity | Specific for ApoA1, No cross reaction to Apo AII or Apo B |
Reconstitution & Storage | 15mM Potassium Phosphate, 0.85% Sodium Chloride, pH 7.5, 0.1% NaN3 Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | Anti-APOA1 / Apolipoprotein A 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | APOA1 (HGNC:600) |
---|---|
Function | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. |
Cellular Location | Secreted. |
Tissue Location | Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease |
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