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RAB27B Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | O00194 |
| Other Accession | 5874 |
| Reactivity | Human, Mouse, Rat, Monkey, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 24608 Da |
| Dilution | IF (1:50 - 1:250), IHC-P (5 µg/ml), WB (1:250 - 1:2000), |
| Gene ID | 5874 |
|---|---|
| Other Names | RAB27B, C25KG, Ras-related protein Rab-27B |
| Target/Specificity | Detects Rab27b by Western blot in the following human, rat and mouse whole cell lysates and transfected cells with GFP-Rab27b. This antibody is specific for Rab27b. It does not recognise Rab27a protein. |
| Reconstitution & Storage | PBS, 20% glycerol, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Precautions | RAB27B Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RAB27B |
|---|---|
| Function | Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity). |
| Cellular Location | Membrane; Lipid-anchor. Late endosome |
| Tissue Location | Expressed primarily in testis. |
| Volume | 100 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
May be involved in targeting uroplakins to urothelial apical membranes.
References
Chen D.,et al.Biochem. Mol. Med. 60:27-37(1997).
Chen D.,et al.Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
Ramalho J.S.,et al.BMC Genet. 2:2-2(2001).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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