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GABARAPL2 / ATG8 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | P60520 |
| Other Accession | 11345 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 13667 Da |
| Dilution | IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml), |
| Gene ID | 11345 |
|---|---|
| Other Names | GABARAPL2, ATG8, ATG8C, GEF2, FLC3A, GATE-16, GATE16, GEF-2 |
| Target/Specificity | GABARAPL2 antibody is human, mouse and rat reactive. Multiple isoforms of GABARAPL2 are known to exist. |
| Reconstitution & Storage | PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GABARAPL2 / ATG8 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GABARAPL2 (HGNC:13291) |
|---|---|
| Synonyms | FLC3A, GEF2 |
| Function | Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (PubMed:20418806, PubMed:23209295). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295). |
| Cellular Location | Cytoplasmic vesicle, autophagosome. Endoplasmic reticulum membrane. Golgi apparatus {ECO:0000250|UniProtKB:P60519} |
| Tissue Location | Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
References
Okazaki N.,et al.Brain Res. Mol. Brain Res. 85:1-12(2000).
Xin Y.,et al.Genomics 74:408-413(2001).
Storch S.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Song H.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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