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GJB2 / CX26 / Connexin 26 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P29033 |
| Other Accession | 2706 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 26215 Da |
| Dilution | IHC-P (10 µg/ml), WB (1 - 2 µg/ml), |
| Gene ID | 2706 |
|---|---|
| Other Names | GJB2, Connexin 26, Connexin-26, DFNB1A, DFNA3, DFNB1, Gap junction protein beta 2, KID, HID, PPK, NSRD1, CX26, DFNA3A |
| Target/Specificity | GJB2 antibody is human specific. |
| Reconstitution & Storage | PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GJB2 / CX26 / Connexin 26 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GJB2 |
|---|---|
| Function | Structural component of gap junctions (PubMed:16849369, PubMed:17551008, PubMed:19340074, PubMed:19384972, PubMed:21094651, PubMed:26753910). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (PubMed:17551008, PubMed:19340074, PubMed:21094651, PubMed:26753910). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:16849369, PubMed:19384972, PubMed:21094651). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Note=Colocalizes with GJB4 at gap junction plaques in the cochlea. {ECO:0000250|UniProtKB:Q00977} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
References
Lee S.W.,et al.J. Cell Biol. 118:1213-1221(1992).
Hamelmann C.,et al.Hum. Mutat. 18:84-85(2001).
Gasmelseed N.M.A.,et al.Hum. Mutat. 23:206-207(2004).
Najmabadi H.,et al.Am. J. Med. Genet. A 133:132-137(2005).
Joseph A.Y.,et al.Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
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