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SRR / Serine Racemase Antibody (aa131-340)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q9GZT4 |
| Other Accession | 63826 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 36566 Da |
| Dilution | IHC-P (5 µg/ml), |
| Gene ID | 63826 |
|---|---|
| Other Names | SRR, D-serine dehydratase, ISO1, L-serine ammonia-lyase, L-serine dehydratase, ILV1, Serine racemase, D-serine ammonia-lyase |
| Target/Specificity | Human SRR / Serine Racemase |
| Reconstitution & Storage | 0.1 M Tris-glycine, pH 7, 20% Glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
| Precautions | SRR / Serine Racemase Antibody (aa131-340) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SRR |
|---|---|
| Function | Catalyzes the synthesis of D-serine from L-serine (PubMed:20106978, PubMed:23391306, PubMed:29277459). D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity). |
| Tissue Location | Expressed in the cerebellum, hippocampus, dorsolateral prefrontal cortex, and in motor neurons and glial cells of the lumbar spinal cord (at protein level) (PubMed:17880399, PubMed:24138986). Increased in the dorsolateral prefrontal cortex of schizophrenic patients (at protein level) (PubMed:17880399). Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei (PubMed:15193426). Expressed in heart, skeletal muscle, kidney, and liver (PubMed:15193426) |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
References
De Miranda J.,et al.Gene 256:183-188(2000).
Xia M.,et al.Brain Res. Mol. Brain Res. 125:96-104(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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