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HMGIY / HMGA1 Antibody (aa1-53)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | P17096 |
| Other Accession | 3159 |
| Reactivity | Human, Mouse, Rat, Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 11676 Da |
| Dilution | IHC-P (10 µg/ml), |
| Gene ID | 3159 |
|---|---|
| Other Names | HMGA1, High mobility group protein A1, High mobility group protein R, HMG-R, Hmg-i, HMGIY, High mobility group AT-hook 1, HMG-I(Y), HMGA1A |
| Target/Specificity | Human HMGIY / HMGA1 |
| Reconstitution & Storage | PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
| Precautions | HMGIY / HMGA1 Antibody (aa1-53) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HMGA1 |
|---|---|
| Synonyms | HMGIY |
| Function | HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. |
| Cellular Location | Nucleus. Chromosome. |
| Volume | 100 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
References
Eckner R.,et al.Nucleic Acids Res. 17:5947-5959(1989).
Johnson K.R.,et al.Mol. Cell. Biol. 9:2114-2123(1989).
Friedmann M.,et al.Nucleic Acids Res. 21:4259-4267(1993).
Nagpal S.,et al.J. Biol. Chem. 274:22563-22568(1999).
Mungall A.J.,et al.Nature 425:805-811(2003).
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