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GPI Antibody (clone 4B11)

Mouse Monoclonal Antibody

     
  • IHC - GPI Antibody (clone 4B11) ALS16950
    Anti-GPI antibody IHC staining of human kidney.
    detail
  • IF - GPI Antibody (clone 4B11) ALS16950
    Anti-GPI mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently...
    detail
  • WB - GPI Antibody (clone 4B11) ALS16950
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GPI...
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P06744
Other Accession 2821
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 4B11
Calculated MW 63147 Da
Dilution IF (1:100), IHC-P (10 µg/ml), WB (1:2000),
Additional Information
Gene ID 2821
Other Names GPI, AMF, Autocrine motility factor, Glucose phosphate isomerase, Hexose monophosphate isomerase, Hexosephosphate isomerase, Neuroleukin, Oxoisomerase, Phosphoglucose isomerase, Phosphohexomutase, Phosphohexose isomerase, SA36, PGI, SA-36, Glucose-6- ...
Target/Specificity Human GPI
Reconstitution & Storage PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsGPI Antibody (clone 4B11) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPI {ECO:0000303|PubMed:2387591, ECO:0000312|HGNC:HGNC:4458}
Function In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:11004567, PubMed:3352745). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:11004567, PubMed:3352745).
Cellular Location Cytoplasm. Secreted
Research Areas
Citations (0)
citation

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Background

Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.

References

Gurney M.E.,et al.Submitted (MAR-1987) to the EMBL/GenBank/DDBJ databases.
Yakirevich E.,et al.Biol. Reprod. 62:1016-1023(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Walker J.I.H.,et al.Genomics 7:638-643(1990).

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$ 467.50
Cat# ALS16950
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