WFS1 Antibody (aa183-232)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | O76024 |
Other Accession | 7466 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 100292 Da |
Dilution | ELISA (1:10000), IHC-P (5 µg/ml), WB (1:500 - 1:1000), |
Gene ID | 7466 |
---|---|
Other Names | WFS1, DIDMOAD, DFNA14, DFNA6, Wolframin, WFS, WFSL, Wolfram syndrome 1 (wolframin), DFNA38, WFRS, Wolfram Syndrome 1 |
Target/Specificity | Wolframin antibody detects endogenous levels of Wolframin. |
Reconstitution & Storage | PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C. |
Precautions | WFS1 Antibody (aa183-232) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | WFS1 |
---|---|
Function | Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (PubMed:16989814). Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism (PubMed:23035048). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle. Note=Co-localizes with ATP6V1A in the secretory granules in neuroblastoma cell lines |
Tissue Location | Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store.
References
Strom T.M.,et al.Hum. Mol. Genet. 7:2021-2028(1998).
Inoue H.,et al.Nat. Genet. 20:143-148(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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