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RAB4A / RAB4 Antibody (clone 4E11)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, FC |
|---|---|
| Primary Accession | P20338 |
| Other Accession | 5867 |
| Reactivity | Human, Mouse, Monkey |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 4E11 |
| Calculated MW | 24390 Da |
| Dilution | ELISA (1:10000), Flo (1:200 - 1:400), IHC-P (10 µg/ml), WB (1:500 - 1:2000), |
| Gene ID | 5867 |
|---|---|
| Other Names | RAB4A, HRES-1/RAB4, Oncogene RAB4, RAB4, Ras-related protein Rab-4A |
| Target/Specificity | Human RAB4A / RAB4 |
| Reconstitution & Storage | PBS, 0.05% sodium azide, 0.5% protein stabilizer. Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
| Precautions | RAB4A / RAB4 Antibody (clone 4E11) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RAB4A |
|---|---|
| Synonyms | RAB4 |
| Function | Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:15907487, PubMed:16034420). Involved in protein transport (PubMed:29425100). Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100). Acts as a regulator of platelet alpha- granule release during activation and aggregation of platelets (By similarity). |
| Cellular Location | Membrane; Peripheral membrane protein. Cytoplasm Early endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Recycling endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1 |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Protein transport. Probably involved in vesicular traffic (By similarity).
References
Zahraoui A.,et al.J. Biol. Chem. 264:12394-12401(1989).
Nagy G.,et al.J. Biol. Chem. 281:34574-34591(2006).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
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