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LAMP1 / CD107a Antibody (clone 5H6)

Mouse Monoclonal Antibody

     
  • IHC - LAMP1 / CD107a Antibody (clone 5H6) ALS16826
    Anti-LAMP1 / CD107a antibody IHC staining of human brain, cerebellum.
    detail
  • IHC - LAMP1 / CD107a Antibody (clone 5H6) ALS16826
    Anti-LAMP1 / CD107a antibody IHC staining of human small intestine.
    detail
  • ICC - LAMP1 / CD107a Antibody (clone 5H6) ALS16826
    HeLa cells staining with CD107a / LAMP1 antibody (red), and counterstained with chicken...
    detail
  • WB - LAMP1 / CD107a Antibody (clone 5H6) ALS16826
    Western strip blots of HeLa cell crude extracts stained with anti LAMP1 antibody CD107a / LAMP1...
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P11279
Other Accession 3916
Reactivity Human, Mouse, Rat, Pig, Bovine
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 5H6
Calculated MW 44882 Da
Dilution IF (1:2000), IHC-P (10 µg/ml), WB (1:10000),
Additional Information
Gene ID 3916
Other Names LAMP1, CD107a, CD107a antigen, LAMP-1, LGP120, LAMPA
Reconstitution & Storage PBS, 10 mM sodium azide. +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsLAMP1 / CD107a Antibody (clone 5H6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LAMP1 {ECO:0000303|PubMed:23632890, ECO:0000312|HGNC:HGNC:6499}
Function Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (PubMed:37390818). Also plays an important role in NK-cells cytotoxicity (PubMed:2022921, PubMed:23632890). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (PubMed:7685349).
Cellular Location Lysosome membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Cytolytic granule membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). {ECO:0000250|UniProtKB:P05300, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

References

Fukuda M.,et al.J. Biol. Chem. 263:18920-18928(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Mane S.M.,et al.Arch. Biochem. Biophys. 268:360-378(1989).

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$ 467.50
Cat# ALS16826
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