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SDCCAG8 Antibody (aa469-483)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q86SQ7 |
| Other Accession | 10806 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 82682 Da |
| Dilution | ELISA (1:32000), IHC-P (5 µg/ml), |
| Gene ID | 10806 |
|---|---|
| Other Names | SDCCAG8, Antigen NY-CO-8, CCCAP, CCCAP SLSN7, HCCCAP, NPHP10, NY-CO-8, HSPC085, SLSN7, BBS16 |
| Target/Specificity | Human SDCCAG8. |
| Reconstitution & Storage | Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
| Precautions | SDCCAG8 Antibody (aa469-483) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SDCCAG8 |
|---|---|
| Synonyms | CCCAP, NPHP10 |
| Function | Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062). |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Cell junction. Note=Located at the distal ends of both centrioles and colocalizes to centrosomes throughout the cell cycle |
| Tissue Location | Expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa, colon and renal cancer tumors |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). May play a role in ciliogenesis.
References
Kenedy A.A.,et al.Gene 303:35-46(2003).
Zhang Q.-H.,et al.Genome Res. 10:1546-1560(2000).
Scanlan M.J.,et al.Int. J. Cancer 76:652-658(1998).
Andersen J.S.,et al.Nature 426:570-574(2003).
Otto E.A.,et al.Nat. Genet. 42:840-850(2010).
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