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SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 9A1)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IP, FC |
|---|---|
| Primary Accession | P01009 |
| Other Accession | 5265 |
| Reactivity | Human, Monkey, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 9A1 |
| Calculated MW | 46737 Da |
| Dilution | Flo (1:100), IHC-P (10 µg/ml), WB (1:500 - 1:1000), |
| Gene ID | 5265 |
|---|---|
| Other Names | SERPINA1, A1A, A1AT, AAT, Alpha 1 Antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Alpha-1-antitrypsin, Alpha1AT, PRO2275, Alpha-1-antitrypsin null, PI1, Serpin A1 |
| Target/Specificity | Human SERPINA1 / Alpha 1 Antitrypsin |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
| Precautions | SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 9A1) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SERPINA1 (HGNC:8941) |
|---|---|
| Synonyms | AAT, PI |
| Function | Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. |
| Cellular Location | Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum |
| Tissue Location | Ubiquitous. Expressed in leukocytes and plasma. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
References
Bollen A.,et al.DNA 2:255-264(1983).
Long G.L.,et al.Biochemistry 23:4828-4837(1984).
Rosenberg S.,et al.Nature 312:77-80(1984).
Ciliberto G.,et al.Cell 41:531-540(1985).
Nukiwa T.,et al.J. Biol. Chem. 261:15989-15994(1986).
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