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VTN / Vitronectin Antibody
Sheep Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E, IE |
|---|---|
| Primary Accession | P04004 |
| Other Accession | 7448 |
| Reactivity | Human |
| Host | Sheep |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 54306 Da |
| Dilution | IHC-P (5 µg/ml), |
| Gene ID | 7448 |
|---|---|
| Other Names | VTN, Epibolin, Serum-spreading factor, VNT, S-protein, Somatomedin B, V75, VN, Complement S-protein, Serum spreading factor, Vitronectin |
| Target/Specificity | Specific for vitronectin as demonstrated by immunoelectrophoresis. A single precipitin arc is observed with normal plasma, of identical mobility to that obtained with purified vitronectin. |
| Reconstitution & Storage | 0.01 M HEPES, pH 7.4, 0.15 M sodium chloride, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | VTN / Vitronectin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VTN |
|---|---|
| Function | Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. |
| Cellular Location | Secreted, extracellular space |
| Tissue Location | Expressed in the retina pigment epithelium (at protein level) (PubMed:25136834). Expressed in plasma (at protein level) (PubMed:2448300). Expressed in serum (at protein level) (PubMed:29567995). |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
References
Suzuki S.,et al.EMBO J. 4:2519-2524(1985).
Suzuki S.,et al.Submitted (JUN-1986) to the PIR data bank.
Jenne D.E.,et al.EMBO J. 4:3153-3157(1985).
Jenne D.E.,et al.Biochemistry 26:6735-6742(1987).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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