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HSPG2 / Perlecan Antibody (clone A7L6)
Rat Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC, IP, IHC-F |
|---|---|
| Primary Accession | P98160 |
| Other Accession | 3339 |
| Reactivity | Human, Mouse, Rat, Bovine |
| Host | Rat |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone Names | A7L6 |
| Calculated MW | 468830 Da |
| Dilution | IHC-Fr (1:50), IP (1:100 - 1:1000), |
| Gene ID | 3339 |
|---|---|
| Other Names | HSPG2, Endorepellin (domain V region), HSPG, Heparan sulfate proteoglycan 2, Perlecan, Perlecan proteoglycan, SJA, SJS1, PRCAN, SJS |
| Target/Specificity | Recognizes domain IV of the core protein of the large heparan sulphate proteoglycan or perlecan. The reactivity is independent of the galactosaminoglycan moieties. Therefore, the epitope is not sensitive to heparitinase treatment. |
| Reconstitution & Storage | PBS containing 0.09% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | HSPG2 / Perlecan Antibody (clone A7L6) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HSPG2 |
|---|---|
| Function | Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. [LG3 peptide]: Has anti-angiogenic properties that require binding of calcium ions for full activity. |
| Cellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. Secreted |
| Tissue Location | Detected in cerebrospinal fluid, fibroblasts and urine (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.
References
Murdoch A.D.,et al.J. Biol. Chem. 267:8544-8557(1992).
Kallunki P.,et al.J. Cell Biol. 116:559-571(1992).
Gregory S.G.,et al.Nature 441:315-321(2006).
Cohen I.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:10404-10408(1993).
Nicole S.,et al.Nat. Genet. 26:480-483(2000).
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