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VWF / Von Willebrand Factor Antibody (FITC)

Sheep Polyclonal Antibody

     
  • IHC - VWF / Von Willebrand Factor Antibody (FITC) ALS16578
    Anti-VWF / Von Willebrand Factor antibody IHC staining of human vessel, serum.
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  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, IHC-F
Primary Accession P04275
Other Accession 7450
Reactivity Human
Host Sheep
Clonality Polyclonal
Isotype IgG
Calculated MW 309265 Da
Dilution IHC-Fr (1:50 - 1:100), IHC-P (1:100),
Additional Information
Gene ID 7450
Other Names VWF, Coagulation factor VIII VWF, F8VWF, VWD, Von Willebrand factor
Target/Specificity Human von Willebrand factor, a glycoprotein synthesized in endothelial cells and megakaryocytes which circulates in the blood associated with factor VIII in a non-covalent complex
Reconstitution & Storage PBS, pH 7.2, 0.09% sodium azide. Short term 4 C, Long term -20 C, Product is photosensitive and should be protected from light. Avoid freeze-thaw cycles.
PrecautionsVWF / Von Willebrand Factor Antibody (FITC) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VWF
Synonyms F8VWF
Function Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Cellular Location Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage granules
Tissue Location Plasma.
Research Areas
Citations (0)
citation

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Background

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.

References

Bonthron D.,et al.Nucleic Acids Res. 14:7125-7128(1986).
Mancuso D.J.,et al.J. Biol. Chem. 264:19514-19527(1989).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Verweij C.L.,et al.EMBO J. 5:1839-1847(1986).

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$ 467.50
Cat# ALS16578
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