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JCHAIN / Ig J Chain Antibody (clone 3H7)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P01591 |
| Other Accession | 3512 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 3H7 |
| Calculated MW | 18099 Da |
| Dilution | IHC-P (10 µg/ml), WB (1:2000), |
| Gene ID | 3512 |
|---|---|
| Other Names | JCHAIN, IGCJ, Immunoglobulin J chain, IGJ, IgJ chain, JCH |
| Target/Specificity | Human IGJ |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
| Precautions | JCHAIN / Ig J Chain Antibody (clone 3H7) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | JCHAIN (HGNC:5713) |
|---|---|
| Synonyms | IGCJ, IGJ |
| Function | Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component. |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:P01592}. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mole J.E.,et al.Biochemistry 16:3507-3513(1977).
Max E.E.,et al.J. Exp. Med. 161:832-849(1985).
Frutiger S.,et al.Biochemistry 31:12643-12647(1992).
Kristiansen T.Z.,et al.Mol. Cell. Proteomics 3:715-728(2004).
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