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Nestin Antibody (clone 10C2)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC, IHC-F |
|---|---|
| Primary Accession | P48681 |
| Other Accession | 10763 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 10C2 |
| Calculated MW | 177439 Da |
| Dilution | IHC-Fr (1:100 - 1:200), IHC-P (10 µg/ml), WB (1:1000 - 1:5000), |
| Gene ID | 10763 |
|---|---|
| Other Names | NES, Nestin, Nbla00170 |
| Target/Specificity | Reacts exclusively with the human nestin protein. No cross-reactivity to rodent nestin. |
| Reconstitution & Storage | PBS containing 0.09% sodium azide. Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
| Precautions | Nestin Antibody (clone 10C2) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NES |
|---|---|
| Function | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen- stimulated proliferation of neural progenitor cells (By similarity). |
| Tissue Location | CNS stem cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).
References
Dahlstrand J.,et al.J. Cell Sci. 103:589-597(1992).
Gregory S.G.,et al.Nature 441:315-321(2006).
Yaworsky P.J.,et al.Dev. Biol. 205:309-321(1999).
Ohira M.,et al.Cancer Lett. 197:63-68(2003).
Olsen J.V.,et al.Cell 127:635-648(2006).
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