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CEA / Carcinoembryonic Antigen Antibody (clone PARLAM 4)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC, IHC-F, FC |
|---|---|
| Primary Accession | P06731 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | PARLAM 4 |
| Calculated MW | 76796 Da |
| Dilution | IHC-Fr (1:25 - 1:100), IHC-P (10 µg/ml), WB (1:100 - 1:500), |
| Gene ID | 1048 |
|---|---|
| Other Names | Carcinoembryonic antigen-related cell adhesion molecule 5, Carcinoembryonic antigen, CEA, Meconium antigen 100, CD66e, CEACAM5, CEA |
| Target/Specificity | Most polyclonal CEA antisera show cross-reactivity with related antigens such as biliary glycoprotein (BGP) and non-specific cross-reacting antigen 1/11 (NCA). Does not show cross reactivity, neither with BGP nor with NCA. In immunoblotting the antib ... |
| Reconstitution & Storage | PBS with 0.09% Sodium Azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | CEA / Carcinoembryonic Antigen Antibody (clone PARLAM 4) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CEACAM5 |
|---|---|
| Synonyms | CEA |
| Function | Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface Note=Localized to the apical glycocalyx surface |
| Tissue Location | Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. |
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 467.50
Cat# ALS16515
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