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CD34 Antibody (clone EP88)
Rabbit Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IHC-F |
|---|---|
| Primary Accession | P28906 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone Names | EP88 |
| Calculated MW | 41kDa |
| Dilution | IHC-Fr (1:50-1:200), IHC-P (1:100), |
| Gene ID | 947 |
|---|---|
| Other Names | Hematopoietic progenitor cell antigen CD34, CD34, CD34 |
| Reconstitution & Storage | Store at 2-8°C |
| Precautions | CD34 Antibody (clone EP88) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD34 |
|---|---|
| Function | Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
References
Simmons D.L.,et al.J. Immunol. 148:267-271(1992).
Satterthwaite A.B.,et al.Genomics 12:788-794(1992).
Nakamura Y.,et al.Exp. Hematol. 21:236-242(1993).
Freund D.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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