TSPAN1 / TM4SF Antibody (aa132-227)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | O60635 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 26kDa |
Dilution | IHC-P (5 µg/ml), WB (1:500-1:3000), |
Gene ID | 10103 |
---|---|
Other Names | Tetraspanin-1, Tspan-1, Tetraspan NET-1, Tetraspanin TM4-C, TSPAN1 |
Target/Specificity | Human TSPAN1 / TM4SF |
Reconstitution & Storage | Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
Precautions | TSPAN1 / TM4SF Antibody (aa132-227) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TSPAN1 |
---|---|
Function | Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:30066932, PubMed:30291375). Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways (By similarity). Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK (PubMed:30291375). Promotes also the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process (PubMed:21836059). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
References
Todd S.C.,et al.Biochim. Biophys. Acta 1399:101-104(1998).
Rubinstein E.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Puls K.L.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
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