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CAPN1 / Calpain 1 Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - CAPN1 / Calpain 1 Antibody (Internal) ALS16293
    CAPN1 antibody (0.3 ug/ml) staining of Human Spleen lysate (35 ug protein in RIPA buffer).
    detail
  • IHC - CAPN1 / Calpain 1 Antibody (Internal) ALS16293
    Anti-CAPN1 / Calpain 1 antibody IHC staining of human kidney.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P07384
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 82kDa
Dilution ELISA (1:32000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 823
Other Names Calpain-1 catalytic subunit, 3.4.22.52, Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Cell proliferation-inducing gene 30 protein, Micromolar-calpain, muCANP, CAPN1, CANPL1
Target/Specificity Human CAPN1 / Calpain 1. Reported variants represent identical protein: NP_001185797.1, NP_005177.2, NP_001185798.1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsCAPN1 / Calpain 1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAPN1 (HGNC:1476)
Synonyms CANPL1
Function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626).
Cellular Location Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719)
Tissue Location Ubiquitous.
Research Areas
Citations (0)
citation

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Background

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

References

Aoki K.,et al.FEBS Lett. 205:313-317(1986).
Sorimachi H.,et al.Biol. Chem. Hoppe-Seyler 371:171-176(1990).
Kim J.W.,et al.Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
Melloni E.,et al.Biochem. Biophys. Res. Commun. 229:193-197(1996).
Michetti M.,et al.FEBS Lett. 392:11-15(1996).

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$ 467.50
Cat# ALS16293
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