AIF1 / IBA1 Antibody (aa85-147)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | P55008 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 17kDa |
Dilution | IHC-P (1:100), WB (1:500-1:3000), |
Gene ID | 199 |
---|---|
Other Names | Allograft inflammatory factor 1, AIF-1, Ionized calcium-binding adapter molecule 1, Protein G1, AIF1, G1, IBA1 |
Target/Specificity | Human AIF1 / IBA1 |
Reconstitution & Storage | Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
Precautions | AIF1 / IBA1 Antibody (aa85-147) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | AIF1 |
---|---|
Synonyms | G1, IBA1 |
Function | Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. |
Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O70200}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O70200}; Peripheral membrane protein {ECO:0000250|UniProtKB:O70200}; Cytoplasmic side {ECO:0000250|UniProtKB:O70200}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:O70200}. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis {ECO:0000250|UniProtKB:O70200} |
Tissue Location | Detected in T-lymphocytes and peripheral blood mononuclear cells. |
Volume | 50 µl |
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Background
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
References
Albertella M.R.,et al.Hum. Mol. Genet. 3:793-799(1994).
Holzinger I.,et al.Immunogenetics 42:315-322(1995).
Autieri M.V.,et al.Biochem. Biophys. Res. Commun. 228:29-37(1996).
Utans U.,et al.Transplantation 61:1387-1392(1996).
de Baey A.,et al.Genomics 45:591-600(1997).
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