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TRAM1 Antibody (aa310-374)

Rabbit Polyclonal Antibody

     
  • WB - TRAM1 Antibody (aa310-374) ALS16250
    Sample (30 ug of whole cell lysate). A: H1299. 10% SDS PAGE. TRAM1 antibody diluted at 1:1000.
    detail
  • ICC - TRAM1 Antibody (aa310-374) ALS16250
    Immunofluorescence of methanol-fixed HeLa using TRAM1 antibody at 1:500 dilution.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC
Primary Accession Q15629
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Dilution ICC (1:100-1:1000), IHC-P (1:100), WB (1:500-1:3000)
Additional Information
Gene ID 23471
Other Names Translocating chain-associated membrane protein 1, TRAM1, TRAM
Target/Specificity Human TRAM1
Reconstitution & Storage Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsTRAM1 Antibody (aa310-374) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRAM1 (HGNC:20568)
Function Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel (PubMed:12475939, PubMed:1315422, PubMed:32013668, PubMed:8616892, PubMed:9506517). Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER (PubMed:9506517). May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport (PubMed:32013668). Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane (PubMed:8616892). Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane (PubMed:12475939). Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome (PubMed:20430023).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Research Areas
Citations (0)
citation

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Background

Stimulatory or required for the translocation of secretory proteins across the ER membrane.

References

Goerlich D.,et al.Nature 357:47-52(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Olsen J.V.,et al.Cell 127:635-648(2006).
Daub H.,et al.Mol. Cell 31:438-448(2008).

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$ 467.50
Cat# ALS16250
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