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NDUFS2 Antibody (aa200-430)

Rabbit Polyclonal Antibody

     
  • WB - NDUFS2 Antibody (aa200-430) ALS16220
    Sample (30 ug of whole cell lysate).
    detail
  • WB - NDUFS2 Antibody (aa200-430) ALS16220
    Sample (50 ug of whole cell lysate).
    detail
  • ICC - NDUFS2 Antibody (aa200-430) ALS16220
    NDUFS2 antibody detects NDUFS2 protein at mitochondria by immunofluorescent analysis.
    detail
  • IHC - NDUFS2 Antibody (aa200-430) ALS16220
    Anti-NDUFS2 antibody IHC staining of human kidney.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC
Primary Accession O75306
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 53kDa
Dilution ICC (1:100-1:1000), IHC-P (7.5 µg/ml), WB (1:1000-1:10000)
Additional Information
Gene ID 4720
Other Names NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial, 1.6.5.3, 1.6.99.3, Complex I-49kD, CI-49kD, NADH-ubiquinone oxidoreductase 49 kDa subunit, NDUFS2
Target/Specificity Human NDUFS2
Reconstitution & Storage Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsNDUFS2 Antibody (aa200-430) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NDUFS2
Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:22036843, PubMed:30922174, PubMed:28031252). Essential for the catalytic activity of complex I (PubMed:22036843, PubMed:30922174). Essential for the assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (PubMed:30922174). Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity).
Cellular Location Mitochondrion inner membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q641Y2}; Matrix side {ECO:0000250|UniProtKB:Q641Y2}
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

References

Loeffen J.,et al.Biochem. Biophys. Res. Commun. 247:751-758(1998).
Procaccio V.,et al.Mamm. Genome 9:482-484(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS16220
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