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CXCL10 / IP-10 Antibody (aa22-98)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P02778 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 11kDa |
| Dilution | ELISA (1:20000-1:80000), IHC-P (2.5 µg/ml), WB (1:1000-1:2000) |
| Gene ID | 3627 |
|---|---|
| Other Names | C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, Gamma-IP10, IP-10, Small-inducible cytokine B10, CXCL10(1-73), CXCL10, INP10, SCYB10 |
| Target/Specificity | Human IP-10 / CXCL10. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | CXCL10 / IP-10 Antibody (aa22-98) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CXCL10 |
|---|---|
| Synonyms | INP10, SCYB10 |
| Function | Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:11157474, PubMed:22652417, PubMed:7540647). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12663757, PubMed:12750173). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity). |
| Cellular Location | Secreted. |
| Tissue Location | Mainly secreted by monocytes, endothelial cells as well as fibroblasts. Expressed by epithelial cells in thymus (PubMed:11157474). Microglial cells produce CXCL10 in response to viral stimulation (PubMed:12663757). |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
References
Luster A.D.,et al.Nature 315:672-676(1985).
Proost P.,et al.J. Immunol. 150:1000-1010(1993).
Tensen C.P.,et al.J. Invest. Dermatol. 112:716-722(1999).
Hensbergen P.J.,et al.Eur. J. Biochem. 268:4992-4999(2001).
Loos T.,et al.Blood 112:2648-2656(2008).
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