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CRYAB / Alpha B Crystallin Antibody (clone 6D11)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, IP, FC |
|---|---|
| Primary Accession | P02511 |
| Reactivity | Human, Rat, Monkey |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6D11 |
| Calculated MW | 20kDa |
| Dilution | Flo (1:100), IF (1:50-1:100), IHC-P (10 µg/ml), WB (1:500-1:1000) , |
| Gene ID | 1410 |
|---|---|
| Other Names | Alpha-crystallin B chain, Alpha(B)-crystallin, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component, CRYAB, CRYA2 |
| Target/Specificity | Human CRYAB / Alpha B Crystallin |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | CRYAB / Alpha B Crystallin Antibody (clone 6D11) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CRYAB (HGNC:2389) |
|---|---|
| Synonyms | CRYA2, HSPB5 |
| Function | May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity). |
| Cellular Location | Cytoplasm. Nucleus Secreted. Lysosome {ECO:0000250|UniProtKB:P23927}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326). Localizes at the Z- bands and the intercalated disk in cardiomyocytes (PubMed:28493373) Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). |
| Tissue Location | Lens as well as other tissues (PubMed:2387586, PubMed:838078). Expressed in myocardial tissue (PubMed:28493373) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
References
Kramps J.A.,et al.FEBS Lett. 74:82-84(1977).
Dubin R.A.,et al.Genomics 7:594-601(1990).
Iwaki A.,et al.Neurosci. Lett. 140:89-92(1992).
Yu W.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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