ABCC2 Antibody (aa977-1026)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q92887 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 174kDa |
Dilution | ELISA (1:10000), IHC-P (5 µg/ml), WB (1:500-1:1000) |
Gene ID | 1244 |
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Other Names | Canalicular multispecific organic anion transporter 1, ATP-binding cassette sub-family C member 2, Canalicular multidrug resistance protein, Multidrug resistance-associated protein 2, ABCC2, CMOAT, CMOAT1, CMRP, MRP2 |
Target/Specificity | ABCC2 Antibodyantibody detects endogenous levels of ABCC2. |
Reconstitution & Storage | Store at -20°C. |
Precautions | ABCC2 Antibody (aa977-1026) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ABCC2 (HGNC:53) |
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Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)- conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17- glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505). |
Cellular Location | Apical cell membrane; Multi-pass membrane protein. Note=Localized to the apical membrane of enterocytes |
Tissue Location | Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver. Expressed in small intestine (PubMed:28408210). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
References
Taniguchi K.,et al.Cancer Res. 56:4124-4129(1996).
Kool M.,et al.Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
Buechler M.,et al.J. Biol. Chem. 271:15091-15098(1996).
Keppler D.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Tsujii H.,et al.Gastroenterology 117:653-660(1999).
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