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BDH2 Antibody (aa60-71)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9BUT1 |
| Reactivity | Human, Monkey |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 27kDa |
| Dilution | ELISA (1:64000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml) |
| Gene ID | 56898 |
|---|---|
| Other Names | 3-hydroxybutyrate dehydrogenase type 2, 1.1.1.-, 1.1.1.30, Dehydrogenase/reductase SDR family member 6, Oxidoreductase UCPA, R-beta-hydroxybutyrate dehydrogenase, Short chain dehydrogenase/reductase family 15C member 1, BDH2, DHRS6, SDR15C1 |
| Target/Specificity | Human BDH2. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | BDH2 Antibody (aa60-71) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BDH2 {ECO:0000303|PubMed:35150746, ECO:0000312|HGNC:HGNC:32389} |
|---|---|
| Function | NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity) (PubMed:35150746). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L- proline, likely a detoxification mechanism for ketoprolines (PubMed:35150746). Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity). May act as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Detected in liver (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).
References
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
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