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AGR2 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - AGR2 Antibody (N-Terminus) ALS16012
    Western blot analysis of AGR2 in HeLa cell lysate with AGR2 antibody at (A) 1 and (B) 2 ug/ml
    detail
  • IF - AGR2 Antibody (N-Terminus) ALS16012
    Immunofluorescence of AGR2 in human small intestine tissue with AGR2 antibody at 20 ug/ml.
    detail
  • IHC - AGR2 Antibody (N-Terminus) ALS16012
    Anti-AGR2 antibody IHC staining of human prostate.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O95994
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 20kDa
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1-2 µg/ml)
Additional Information
Gene ID 10551
Other Names Anterior gradient protein 2 homolog, AG-2, hAG-2, HPC8, Secreted cement gland protein XAG-2 homolog, AGR2, AG2
Target/Specificity Two isoforms of AGR2 exists as a result of alternative splicing event.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsAGR2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AGR2
Synonyms AG2
Function Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113).
Cellular Location Secreted. Endoplasmic reticulum {ECO:0000250|UniProtKB:O88312}
Tissue Location Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines
Research Areas
Citations (0)
citation

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Background

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.

References

Thompson D.A.,et al.Biochem. Biophys. Res. Commun. 251:111-116(1998).
Zhang J.S.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Fan Y.X.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS16012
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