TRMT2A Antibody (clone 1G8)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
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Primary Accession | Q8IZ69 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 1G8 |
Calculated MW | 69kDa |
Dilution | IHC-P (10 µg/ml), WB (1:2000), |
Gene ID | 27037 |
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Other Names | tRNA (uracil-5-)-methyltransferase homolog A, 2.1.1.-, HpaII tiny fragments locus 9c protein, TRMT2A, HTF9C |
Target/Specificity | Human TRMT2A |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | TRMT2A Antibody (clone 1G8) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TRMT2A {ECO:0000303|PubMed:31361898, ECO:0000312|HGNC:HGNC:24974} |
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Function | S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs (PubMed:31361898, PubMed:33799331, PubMed:34556860). Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs (PubMed:31361898, PubMed:33799331). Also able to mediate the formation of 5-methyl-uridine in some mRNAs (PubMed:34123281). |
Cellular Location | Cytoplasm, cytosol. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
May be involved in nucleic acid metabolism and/or modifications.
References
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham I.,et al.Nature 402:489-495(1999).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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