DAB1 Antibody (aa199-248)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | O75553 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 64kDa |
Dilution | ELISA (1:20000), IF (1:100-1:500), IHC-P (20 µg/ml), WB (1:500-1:1000) , |
Gene ID | 1600 |
---|---|
Other Names | Disabled homolog 1, DAB1 |
Target/Specificity | Dab1 Antibody detects endogenous levels of total Dab1 protein. |
Reconstitution & Storage | Store at -20°C for up to one year. |
Precautions | DAB1 Antibody (aa199-248) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DAB1 |
---|---|
Function | Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development. Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P97318}. |
Tissue Location | Mainly expressed in brain. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Adapter molecule functioning in neural development. May regulate SIAH1 activity (By similarity).
References
Lambert de Rouvroit C.,et al.Genomics 53:246-247(1998).
Fazili Z.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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