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ALDH3A1 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P30838 |
| Reactivity | Human, Mouse |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 50kDa |
| Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.01-0.03 µg/ml) |
| Gene ID | 218 |
|---|---|
| Other Names | Aldehyde dehydrogenase, dimeric NADP-preferring, 1.2.1.5, ALDHIII, Aldehyde dehydrogenase 3, Aldehyde dehydrogenase family 3 member A1, ALDH3A1, ALDH3 |
| Target/Specificity | Human ALDH3A1. Reported variants represent identical protein: NP_001128639.1, NP_000682.3, NP_001128640.1 |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | ALDH3A1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ALDH3A1 |
|---|---|
| Synonyms | ALDH3 |
| Function | ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P47739}. |
| Tissue Location | High levels in stomach, esophagus and lung; low level in the liver and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.
References
Schuuring E.M.D.,et al.Submitted (AUG-1991) to the EMBL/GenBank/DDBJ databases.
Hsu L.C.,et al.J. Biol. Chem. 267:3030-3037(1992).
Hsu L.C.,et al.Adv. Exp. Med. Biol. 328:141-152(1993).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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