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ABCA2 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q9BZC7 |
| Reactivity | Human, Horse, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 270kDa |
| Dilution | ELISA (1:2000), IHC-P (3.75 µg/ml), |
| Gene ID | 20 |
|---|---|
| Other Names | ATP-binding cassette sub-family A member 2, ATP-binding cassette transporter 2, ATP-binding cassette 2, ABCA2, ABC2, KIAA1062 |
| Target/Specificity | Human ABCA2. This antibody is expected to recognize both reported isoforms (NP_001597.2; NP_997698.1). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | ABCA2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ABCA2 (HGNC:32) |
|---|---|
| Synonyms | ABC2, KIAA1062 |
| Function | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). |
| Cellular Location | Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Forms discrete, punctate intracellular vesicles. |
| Tissue Location | [Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.
References
Kaminski W.E.,et al.Biochem. Biophys. Res. Commun. 281:249-258(2001).
Vulevic B.,et al.Cancer Res. 61:3339-3347(2001).
Humphray S.J.,et al.Nature 429:369-374(2004).
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
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